Dioxin and BoHV-1 Infection-Juniper Publishers
JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DAIRY & VETERINARY SCIENCES Introduction 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), commonly known as dioxin, is a widespread, persistent, and toxic environmental pollutant, which can suppress immune response thereby leading to an increased susceptibility to infectious agents, including Bovine herpesvirus-1 (BoHV-1). BoHV-1 is an important cattle pathogen that can cause infectious bovine rhinotracheitis (IBR), infectious pustular vulvovaginitis (IPV), conjunctivitis and abortions. Following infection in bovine cells (MDBK), TCDD significantly enhances BoHV-1 replication, through an anticipation of BoHV-1-induced apoptosis, by interfering with iron homeostasis and stimulating the expression of bICP0, the major regulatory protein of BoHV-1. As consequence, TCDD may be an additional threat for BoHV-1 infection in animals. Dioxin is a persistent environmental contaminant which may induce toxicity, both in humans an...